Biological membranes: The laboratory of fundamental physics

Samo Kralj* and Mitja Kralj

Published: 01 November, 2019 | Volume 2 - Issue 1 | Pages: 038-040

Biological membranes present an essential constituent of living cells. Their main role is to separate the interior of a cell from its surrounding, however allowing the selective transfer of specific material through it. Configuration changes of membranes are often correlated with important biological processes [1-7].

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  1. Deuticke B. Transformation and restoration of biconcave shape of human erythrocytes induced by amphiphilic agents and changes of ionic environment. Biochim. Biophys. Acta. 1968; 163: 494-500. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/4387277
  2. Iglič A, Babnik B, Gimsa U, Kralj-Iglič V. On the role of membrane anisotropy in the beading transition of undulated tubular membrane structures. J Phys A Math Gen. 2006; 38: 8527.
  3. Hurley JH, Boura E, Carlson LA, Różycki B. Membrane Budding. Cell. 2010; 143: 875-887. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/21145455
  4. Jesenek D, Perutková S, Kralj-Iglič V, Kralj S, Iglič A. Exocytotic fusion pore stability and topological defects in the membrane with orientational degree of ordering. Cell Calcium. 2012; 52: 277-282. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/22541648
  5. Lee J, Abdeen AA, Wycislo KL, Fan TM, Kilian KA. Interfacial geometry dictates cancer cell tumorigenicity. Nat Mater. 2016; 15: 856-862. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/27043781
  6. Saw TB, Doostmohammadi A, Nier V, Kocgozlu L, Thampi S, et al. Topological defects in epithelia govern cell death and extrusion. Nature. 2017; 544: 212-216. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/28406198
  7. Kumar G, Ramakrishnan N2, Sain A. Tubulation pattern of membrane vesicles coated with biofilaments. Phys Rev E. 2019; 99: 022414. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30934309
  8. Helfrich W. Elastic properties of lipid bilayers: theory and possible experiments. Zeits Naturforschung. 1973; 28: 693-703. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/4273690
  9. Kralj-Iglič V, Heinrich V, Svetina S, Žekš B. Free energy of closed membrane with anisotropic inclusions. Eur Phys J B. 1999; 10: 5-8.
  10. Perutková Š, Daniel M, Rappolt M, Pabst G, Dolinar G, et al., Elastic deformations in hexagonal phases studied by small-angle X-ray diffraction and simulations. Phys Chem Chem Phys. 2011; 13: 3100-3107. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/21063616
  11. Fournier JB. Nontopological saddle-splay and curvature instabilities from anisotropic membrane inclusions. Phys Rev Lett. 1996; 76: 4436-4439. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/10061289
  12. Mermin ND. The topological theory of defects in ordered media. Rev Mod Phys. 1979; 51: 591.
  13. Mesarec L, Góźdź W, Iglič A, Kralj S. Effective topological charge cancelation mechanism. Sci Rep. 2016; 6: 27117.
  14. Kamien RD. The topological theory of defects in ordered media. Rev Mod Phys. 2002; 74: 953.
  15. Bowick M, Nelson DR, Travesset A. Curvature-induced defect unbinding in toroidal geometries. Phys Rev E. 2004; 69: 041102.
  16. Kralj-Iglic V, Iglic A, Hägerstrand H, Peterlin P. Stable tubular microexovesicles of the erythrocyte membrane induced by dimeric amphiphiles. Phys Rev E. 2000; 61: 4230. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/11088219
  17. Selinger RL, Konya A, Travesset A, Selinger JV. Monte Carlo studies of the XY model on two-dimensional curved surfaces. J Phys Chem B. 2011; 115: 13989-13993. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/21970652
  18. Napoli G, Vergori L. extrinsic curvature effects on nematic shells. Phys Rev Lett. 2012; 108: 207803. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/23003189
  19. Kibble TWB. Topology of cosmic domains and strings. J Phys A Math Gen. 1976; 9: 1387.
  20. Zurek WH. Cosmological experiments in superfluid helium? Nature. 1985; 317: 505.
  21. Giblin JT, Mertens JB, Starkman GD. Departures from the Friedmann-Lemaitre-Robertson-Walker Cosmological Model in an Inhomogeneous Universe: A numerical Examination. Phys Rev Lett. 2016; 116: 251301. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/27391710
  22. Hobson A. There are no particles, there are only fields. Am J Phys. 2013; 81: 211-223.
  23. Skyrme T. A unified field theory of mesons and baryons. Nucl Phys. 1962; 31: 556-559.


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