Research Article

Evaluation of Uranium in Organs of Residents from an Uranium-Rich Region using Teeth as Bioindicators

João DT Arruda-Neto*, Fermin Garcia and Henriette Righi

Published: 26 March, 2020 | Volume 3 - Issue 1 | Pages: 058-062

The Uranium extraction and processing plant of INB (Brazilian Nuclear Industries) is in Caetité, a city located in a region hosting the largest Uranium reserve of the country. The degree of Uranium contamination in the Caetité population was investigated before using teeth as bioindicator, where a quite high Uranium concentration was measured in this region, about 160 times higher than the world-wide average. Radiobiological risks are here evaluated from Uranium burdens in organs as skeleton, kidneys, liver, tissues and blood, which were estimated from transfer coefficients and effective internal doses. This was accomplished by means of calculations with the use of the STATFLUX/ICRP approach, plus a set of Uranium transfer rate parameters as function of individual’s age assuming an uninterrupted exposure over a period of 60 years. It was found that U ingestion rates by residents of Caetité are three orders of magnitude higher than worldwide average, indicating that food and water would exhibit high levels of contamination. Calculated effective internal doses range from a minimum of one to a maximum of three orders of magnitude higher than background doses, for blood and bones respectively. The likelihood that this circumstance could lead to serious health problems as e.g. neoplasia is addressed. The methodology presented in this work offers subsidies for further studies on environmental pollution by radionuclides.

Read Full Article HTML DOI: 10.29328/journal.ijpra.1001023 Cite this Article Read Full Article PDF


Teeth as bioindicator; Uranium contamination; Biokinetics model; Uranium burden in organs; transfer coefficients; Effective internal doses


  1. Fernandes HM, Gomiero LA, Peres V, Franklin MR, Simões Filho FF. Critical analysis of the waste management performance of two uranium production units in Brazil—part II: Caetite production Center. J Environ Manage. 2008; 88: 914–925. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/17619076
  2. Prado GR, Arruda-Neto JD, Sarkis JE, Geraldo LP, Müller RM, et al. Evaluation of Uranium incorporation from contaminated áreas using teeth as bioindicators – a case study. Radiation Protection and Dosimetry. 2008; 130: 249–252. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/18192333
  3. Tsuji LJ, Nieboer E, Karagatzides JD, Kozlovic DR. Elevated dentine lead levels in adult teeth of first nation people from an isolated region of northern Ontario, Canada. Bulletin of Environmental Contamination and Toxicology. 1997; 59; 854-860. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/9400653
  4. Garcia F, Mesa J, Arruda-Neto JDT, Helene O, Vanin V, et al. The STATFLUX code: a statistical method for calculation of flow and set of parameters, based on the Multiple-Compartment Biokinetical Model. Computer Physics Communications. 2007; 176: 347–361.
  5. IAEA Safety Standards Series No. GSG-9 (2018-a), ISBN 978-92-0-102418-3.
  6. IAEA Safety Standards Series No. GSG-10 (2018-b), ISBN 978-92-0-102518-0.
  7. Austin AL, Lord BI, Ellender M, Haines JW & Harrison JD. Microdosimetry for leukaemogenic target cells for bone-incorporated alpha-emitting radionuclides. Radiation Protection Dosimetry. 1998; 79: 391-394.
  8. Austin AL, Ellender M, Haines JW, Harrison JD, Lord BI. Temporal change in microdosimetry to bone marrow and stromal progenitor cells from alpha-particle-emitting radionuclides incorporated in bone. Radiat Res. 1999; 152: S38-S42. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/10564934
  9. Hei TK. Response of Biological Systems to Low Doses of Ionizing Radiation. Health Phys. 2016; 110: 281-282. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26808883
  10. Birchall A, James AC. A microcomputer algorithm for solving first-order compartmental models involving recycling. Health Phys. 1989; 56: 857-868. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/2722508
  11. Press WH, Teukolsky SA, Vettrling WT, Flannery BP. Numerical Recipes in FORTRAN, “The Art of Scientific Computing”. (2nd ed.). Cambridge: Cambridge University Press. 1992.
  12. ICRP-International Commission on Radiological Protection. Publication 69. Age-dependent Doses to Members of the public from intake of radionuclides. Part 3, Ingestion Dose Coefficients: Annals of the ICRP. 1995; 25.
  13. Garcia F, Barioni A, Arruda-Neto JDT, Deppman A, Milian F, et al. Uranium levels in the diet of São Paulo City residents. Environ Int. 2006; 32: 697–703. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/16626805
  14. Steenhout A, Pourtois M. Lead accumulation in teeth as a function of age with different exposures. Br J Ind Med. 1981; 38: 297-303. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/7272245
  15. Leggett RW. An age-specific kinetic model of lead metabolism in humans. Environ Health Perspect. 1993; 101: 598-616. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/8143593
  16. UNSCEAR (United Nations Scientific Committee on the Effects of Atomics Radiations). Report to General Assembly, 93-156. New York: United Nations. 2000.
  17. Arruda-Neto JDT, Tavares MV, Filadelfo M. Concentrations of uranium in animal feed supplements: measurements and dose estimates. J Radioa Nuclear Chem. 1997; 221: 97-104.
  18. Arruda-Neto JD, Guevara MV, Nogueira GP, Saiki M, Cestari AC, Long-term accumulation of uranium in bones of Wistar rats as function of intake dosages. Radiat Prot Dosimetry. 2004b: 112: 385-393. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/15466919
  19. Arruda-Neto JD, Manso Guevara MV, Nogueira GP, Taricano ID, Saiki M, et al. Long-term accumulation and microdistribution of uranium in bone and marrow of Beagle dogs. Int J Radiat Biol. 2004a; 80: 565–575. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/15370968
  20. Singh NP, Wrenn ME. Is the Beagle dog an appropriate experimental animal for extrapolating data to humans on organ distribution patterns of U, Th, and Pu? Health Phys. 1989; 57: 91-96. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/2606709
  21. ATSDR-Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological profile for uranium. Atlanta: ATSDR. 1999.
  22. Chen J, Meyerhof DP, Tracy BL. Model results of kidney burdens from uranium intakes. Health Phys. 2004; 86: 03-11. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/14695003


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