Mirroring the Pyramidal-Neuron Cell Behavior in the Continuous- time Artificial Hopfield Neural Network. What Problems Arise?
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Abstract
This paper provides a mirroring of the voltage dynamics of a biological pyramidal nervous cell in the framework of the continuous-time Hopfield artificial neural network. The initial aim was to identify those elements that can explain the empirically established voltage dynamics of the biological pyramidal nervous cell. We could not achieve this desire because we encountered a major obstacle related to the current dynamics in a circuit where the capacitance is not ideal, as in the lipid bilayer of the membrane of a biological nervous cell. This phenomenon was empirically observed and mathematically described by J. Curie and von Schweidler back in the last century, but was not successfully implemented in the theory of electrical circuits. That is why we stopped at the stage "what problems arise?"
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Megías M, Emri Z, Freund TF, Gulyás AI. Total number and distribution of inhibitory and excitatory synapses on hippocampal CA1 pyramidal cells. Neuroscience. 2001;102(3):527-40. Available from: https://dx.doi.org/10.1016/S0306-4522(00)00496-6.
Sketchy Group, LLC. 2.3 rhabdovirus. SketchyMedical. Archived from the original on 2017 Apr 13.
Elston GN. Cortex, cognition and the cell: new insights into the pyramidal neuron and prefrontal function. Cereb Cortex. 2003 Nov;13(11):1124-38. Available from: https://dx.doi.org/10.1093/cercor/bhg093.
García-López P, García-Marín V, Freire M. Three-dimensional reconstruction and quantitative study of a pyramidal cell of a Cajal histological preparation. J Neurosci. 2006 Nov;26(44):11249-52. Available from: https://dx.doi.org/10.1523/JNEUROSCI.3543-06.2006
Spruston N. Pyramidal neurons: dendritic structure and synaptic integration. Nat Rev Neurosci. 2008 Mar;9(3):206-21. Available from: https://dx.doi.org/10.1038/nrn2286
Georgiev DD, Kolev SK, Cohen E, Glazebrook JF. Computational capacity of pyramidal neurons in the cerebral cortex. Brain Res. 2020 Dec;1748:147069. Available from: https://dx.doi.org/10.1016/j.brainres.2020.147069.
Golding NL, Mickus TJ, Katz Y, Kath WL, Spruston N. Factors mediating powerful voltage attenuation along CA1 pyramidal neuron dendrites. J Physiol. 2005 Oct;568(Pt 1):69-82. Available from: https://dx.doi.org/10.1113/jphysiol.2005.086793
Remy S, Beck H, Yaari Y. Plasticity of voltage-gated ion channels in pyramidal cell dendrites. Curr Opin Neurobiol. 2010 Aug;20(4):503-9. Available from: https://dx.doi.org/10.1016/j.conb.2010.06.006
Magee J, Hoffman D, Colbert C, Johnston D. Electrical and calcium signaling in dendrites of hippocampal pyramidal neurons. Annu Rev Physiol. 1998;60:327-46. Available from: https://dx.doi.org/10.1146/annurev.physiol.60.1.327.
Wong RKS, Traub RD. NETWORKS | Cellular properties and synaptic connectivity of CA3 pyramidal cells: mechanisms for epileptic synchronization and epileptogenesis. In: Schwartzkroin PA, ed. Encyclopedia of Basic Epilepsy Research. Oxford: Academic Press; 2009. p.815-9. Available from: https://dx.doi.org/10.1016/b978-012373961-2.00215-0.
Franceschetti S, Sancini G, Panzica F, Radici C, Avanzini G. Postnatal differentiation of firing properties and morphological characteristics in layer V pyramidal neurons of the sensorimotor cortex. Neuroscience. 1998 Apr;83(4):1013-24. Available from: https://dx.doi.org/10.1016/S0306-4522(97)00463-6.
Berg J, Sorensen SA, Ting JT, Miller JA, Chartrand T, Buchin A, et al. Human neocortical expansion involves glutamatergic neuron diversification. Nature. 2021 Oct;598(7879):151-8. Available from: https://dx.doi.org/10.1038/s41586-021-03813-8.
Gouwens NW, Sorensen SA, Berg J, Lee C, Jarsky T, Ting J, et al. Classification of electrophysiological and morphological neuron types in the mouse visual cortex. Nat Neurosci. 2019 Jul;22(7):1182-95. Available from: https://dx.doi.org/0.1038/s41593-019-0417-0.
Bakken TE, Jorstad NL, Hu Q, Lake BB, Tian W, Kalmbach BE, et al. Comparative cellular analysis of motor cortex in human, marmoset, and mouse. Nature. 2021 Oct;598(7879):111-9. Available from: https://dx.doi.org/10.1038/s41586-021-03465-8.
Kalmbach BE, Buchin A, Long B, Close J, Nandi A, Miller JA, et al. h-Channels contribute to divergent intrinsic membrane properties of supragranular pyramidal neurons in human versus mouse cerebral cortex. Neuron. 2018 Dec;100(5):1194-205.e5. Available from: https://dx.doi.org/10.1016/j.neuron.2018.10.012.
Balint L, Braescu S, Kaslik E. Regions of attraction and applications to control theory. Cambridge Scientific Publishers Ltd; 2008. Edited by Sivasundaram S.
Hodgkin AL, Huxley AF. A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol. 1952;117:500-44.
Weinberg SH. Membrane capacitive memory alters spiking in neurons described by the fractional order Hodgkin-Huxley model. PLoS One. 2015;10(5):e0126629. Available from: https://dx.doi.org/10.1371/journal.pone.0126629.
Balint AM, Balint S, Szabo R. Mathematical description of the ion transport across biological neuron membrane and in biological neuron networks, voltage propagation along neuron axons and dendrites, which use temporal classic Caputo or Riemann-Liouville fractional partial derivatives, is non-objective. MESA. 2021;12(4).
Curie J. Recherches sur le pouvoir inducteur spécifique et sur la conductibilité des corps cristallisés. Ann Chim Phys. 1889;17:384-434.
Curie J. Recherches sur la conductibilité des corps cristallisés. Ann Chim Phys. 1889;18:203-69.
Schweidler ER. Studien über die Anomalien im Verhalten der Dielektrika. Ann Phys. 1907;329(14):711-70. doi:10.1002/andp.19073291407.
Cojocaru AV, Balint S. Are power laws similar to constitutive laws? Can it be incorporated in the same way in the existing equations, boundary conditions, and initial conditions describing real-world phenomena? Is this a way to avoid temporal fractional-order derivatives? MESA.